The present study aimed to isolate bacteria from marine sediments and evaluate their potential on blood clot lysis. Fibrinolytic activity was determined using skim milk agar and plasminogen-free fibrin plate. The clot lysis was assessed into the pre-clotted blood and incubation for 90 min at 37°C and was expressed as percentage of lysis of the clot. Streptokinase and water were used as positive and negative control which exhibited 85% and 2% lysis of clot respectively. Twenty five isolates showed protease activities, while only four of them secreted fibrinolytic enzyme. The highest fibrinolytic activity was shown by Bacillus sp. In conclusion, this result specifies the possibility of developing new fibrinolytic agents from marine sediment bacteria Bacillus sp.
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